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Although not directly tied to BD prevention, the study illustrates how transient inflammation may result in lasting behavioral changes

All three tirzepatide doses were more effective than basal insulin both in reducing HbA 1c (mean differences ranging between 7.66 mmol/mol [0.70%] with tirzepatide 5 mg and 12.02 mmol/mol [1.09%] with tirzepatide 15 mg [ESM Fig

It should be noted that adverse metabolic effects have been observed with traditional -blockers such as atenolol and metoprolol