[cited 2023 Feb 14] 29
Source: Frontiers in Physiology Source: Endocrine Reviews Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. A wide range of seemingly unrelated disorders have underlying pathophysiological mechanisms in common, namely reactive oxygen species (ROS) production, the accumulation of mitochondrial DNA (mtDNA) damage, resulting in mitochondrial dysfunction: Schizophrenia Bipolar disease Dementia Alzheimers disease Epilepsy Migraine headaches Strokes Neuropathic pain Parkinsons disease Ataxia Transient ischemic attack Cardiomyopathy Coronary artery disease Chronic fatigue syndrome Fibromyalgia Retinitis pigmentosa Diabetes Hepatitis C Primary biliary cirrhosis More How Mitochondria May Affect Cognitive Function When someone has cognitive impairment , their ability to think, learn, remember, use judgment, and make decisions is affected, often by an underlying condition
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Preferential transport of glutathione versus glutathione disulfide in rat liver microsomal vesicles
Wasserstoffperoxid (HO): Wird durch die Glutathion-Peroxidase zu Wasser (HO) reduziert, wobei GSH zu GSSG (oxidiertes Glutathion) oxidiert wird
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