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These findings were further corroborated by Western blot analysis, in which we observed increased -H2AX expression, decreased pNPM1 (T199) protein levels and increased expression of autophagosome LC3A/B proteins (Fig

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Hyperglycemia may not cause any symptoms, although in some cases it may cause excessive urination (polyuria) and increased thirst, as we discussed in fall quarter (see Polyuria in Diabetes Mellitus)