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This phenomenon is thought to be due to the inability of cells to restore normal GSH levels or to increased production of reactive oxygen species (ROS), which can damage macromolecules fundamental to cell survival before being deactivated by antioxidant defenses

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doi: 10.1038/s41590-021-00962-w 241 SartoriusR.TrovatoM.MancoR.DApiceL.De BerardinisP

Clinical Chemistry

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doi: 10.1515/BC.2009.033 25