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1 Introduction Chronic kidney disease (CKD) represents a growing global health burden, with increasing mortality and disability-adjusted life years (DALYs) (1)

Factors influencing cost include the number of procedures required, the complexity of the surgeries, anesthesia costs, and surgeon fees

Putting the trial numbers into perspective Historically, anti-obesity drugs produced average weight losses in the single digits (510%), and even the best options rarely approached double-digit percentages at the population level

It also means that combining medication with behavioral strategies, rather than relying on medication alone, produces the most resilient results

Oral bioavailability ranges from 4060%, making subcutaneous or intranasal routes theoretically more efficient, though fewer published studies use those delivery methods

A detailed evaluation might be necessary for some cases