Some studies have identified a correlation between T2DM and oxidative damage or antioxidant status [307309]
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Genau deshalb ist es pharmakologisch interessant denn diese Stabilitt knnte erklren, warum das Peptid nicht nur per Injektion, sondern mglicherweise auch oral wirken kann
Specifically, in addition to anti-thyroid stimulating hormone receptor (TSH-R), Abs have also been found to target insulin-like growth factor 1 receptor on orbital fibroblasts [155], which results in the synthesis of hyaluronan and secretion of interleukin (IL)-1 to IL-16, effectively recruiting autoreactive T cells [156]
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Integrating these datasets with circulating or tissue biomarkers such as 8-hydroxy-2-deoxyguanosine, lipid peroxidation products, or CYGB levels could guide patient selection and dosing for antioxidant therapy [147]