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Our investigation employs the rat INS-1 832/3 -cell line, which naturally expresses the GLP-1R (26) and responds to GLP-1 by potentiating glucose-induced insulin secretion (GSIS) and increasing intracellular cAMP levels (19), making it a valuable model for studying the effect of GLP-1R phospho-site mutants on -cell signalling outputs

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Ozempic for type 2 diabetes) and tirzepatide (Mounjaro), both of which have established safety profiles and are subject to NICE technology appraisal guidance

Under physiological conditions, hepatic ECM functions not only as a structural scaffold but also as a dynamic regulator of intercellular signaling, influencing lipid metabolism, immune homeostasis, and fibrogenesis (89)

Schilling et al., Cancer-Germline Antigen expression discriminates clinical outcome to CTLA-4 blockade