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Average weight loss of 15% of body weight when combined with diet and exercise

The trial itself explicitly concluded that while the drug showed promise, further studies were necessary to establish whether setmelanotide could elicit clinically meaningful weight loss in a subset of the MC4R -deficient obese population

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The American Association of Clinical Endocrinologists and the American Diabetes Association both emphasize site rotation as a key component of injectable medication management

Our clinical findings suggest that this was not the case for most patients in our cohort