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Body weight declined by 11.6% with tirzepatide compared with 4.8% with dulaglutide, a 6.8% difference

This leads to reduced appetite, slower digestion, and improved calorie control

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Mechanistically, GLP-1 receptor agonists have demonstrated anti-inflammatory properties in preclinical models through multiple pathways

H 2 S production may be involved in vascular smooth muscle cell relaxation through regulating the opening/closing of potassium channels and/or enhancing NO-dependent signaling pathway (reviewed in 53)

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