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PCSK9 plays a key role in regulating cholesterol homeostasis by increasing the degradation of LDLR, which clears cholesterol from the bloodstream (Go and Mani, 2012) without impacting LDLR synthesis (Maxwell et al., 2005)

The result is a self-perpetuating cycle: contraction leads to ischemia, which leads to energy crisis, which prevents the muscle from relaxing

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Sjholm , Bennet L, Nilsson PM (2025) Cognitive dysfunction in diabetesthe forgotten diabetes complication: a narrative review

The prescribing information advises discontinuing Ozempic at least two months before a planned pregnancy due to the long washout period for semaglutide