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Lee HC, Shah JJ, Orlowski RZ

They are also believed to have a role in improving the energy level and immune system function, although strong clinical evidence supporting these effects remains limited

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Interest broadened sharply after Yang and colleagues (Cell, 2014) used targeted metabolomic profiling across twelve ferroptosis-inducing small molecules and found that glutathione depletion converges on inactivation of the selenoenzyme glutathione peroxidase 4, placing glutathione availability directly upstream of iron-dependent lipid peroxidation