When comparing peptide 14 to equimolar dosing of the GLP-1R mono-agonist liraglutide, which exhibits similar mGLP-1R cAMP potency and half-life, peptide 14 approximately doubled (30%) body weight loss relative to liraglutide (15%) over 32 days in DIO mice
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Both are injected once weekly using pre-filled pens, come in escalating dose strengths (2.5 mg to 15 mg), and are manufactured under FDA Current Good Manufacturing Practice (CGMP) standards
It is an endogenous neuroactive steroid with antidepressant and anxiolytic activity but poor oral bioavailability because of high first-pass hepatic metabolism, thus limiting its use as an oral drug
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