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Structural comparison of the GSH-bound OsDHAR and GSH-bound OaGST structures revealed that the binding position of GSH is very similar to the H-site binding, although the residues involved in the H-site binding of GSH are very different from each other

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8.7 Hepatic Impairment No difference in the pharmacokinetics of TRESIBA was identified in a study comparing healthy subjects and subjects with hepatic impairment (mild, moderate, and severe hepatic impairment) [see Clinical Pharmacology (12.3)]