Researchers have also shown that semaglutide impacts the reward and punishment systems in the brains of mice, particularly in the nucleus accumbens region, which is part of the limbic system
doi: 10.1097/MNH.0000000000000505 [DOI] [PMC free article] [PubMed] [Google Scholar] 124.Zaresharifi S, Niroomand M, Borran S, Dadkhahfar S
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GLP-1 neurons that target one region, such as the hypothalamus, thalamus, or bed nucleus of the stria terminalis, have axon collaterals that branch widely and reach every central target that is known to receive GLP-1 input, including the spinal cord
What started as a diabetes breakthrough has unexpectedly become one of medicines most versatile tools, with benefits extending far beyond blood sugar control
Additional factors such as increased release of adiponectin from adipose tissue, amelioration of insulin resistance in liver and peripheral tissues, and improved circulatory lipid profile all contribute to the reduced risk of ASCVD (267)
