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This suggests that ART, in combination with residual HIV-induced inflammation, may contribute to accelerated biological aging(inflammaging), potentially underlying the increased risk of age-related comorbidities such as neurocognitive decline, cardiovascular disease, and frailty observed in PLWH (114)

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The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place