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Notably, avidin-conjugated dexamethasone demonstrated superior efficacy in inhibiting IL-1-driven aggrecan breakdown in cartilage explant cultures compared with soluble dexamethasone, 63 underscoring the potential of this approach

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Prior to the targeted synthesis and study of these peptides, research into growth hormone modulation and metabolic signaling relied largely on less specific hormonal interventions and generalized secretagogues