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However, while promising, these findings also underscore the need for further clinical research, particularly large-scale, controlled studies, to better understand its mechanisms of action, optimal dosing, and long-term safety

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Annu Rev Physiol (2016) 78:27799.10.1146/annurev-physiol-021115-105439 20 NakamuraEHasumuraMUneyamaHToriiK

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Table 2: Variation of regional brain metabolite levels with diagnosis group, age, and sex as fixed effects in robust linear mixed-effects (LME) models