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Citri A, Malenka RC

The LIR domain presents an attractive target for designing ligands that interact with the LC3 subfamily through a structure-based drug design strategy

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"Bulk Drug Substances Nominated for Use in Compounding Under Section 503A of the Federal Food, Drug, and Cosmetic Act." FDA Nominated Substances List, 2023

Effectiveness: In a study of 2,539 adults with obesity or overweight plus at least one weight-related medical condition (excluding diabetes), the average weight loss at 72 weeks was 15% with 5 mg weekly doses of tirzepatide, 19.5% with 10 mg doses, and almost 21% with 15 mg doses

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