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Glucagon-like peptide-1 ( GLP-1 ) receptor agonists, such as semaglutide (Wegovy) or tirzepatide (Zepbound), reduce hunger and cravings, making it easier to maintain a calorie deficit during plateaus

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By doing so, these injectables assist in weight loss by reducing cravings and promoting a feeling of fullness after eating smaller portions

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[18] [22] In December 2025, an oral version of semaglutide, sold under the brand name Wegovy, was approved in the US for weight management