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Those investigators also provided pooled all-cause and cause-specific mortality rates, which were 16.8 per 1,000 PY for all-cause mortality, 4.2 per 1,000 PY for cardiac-specific mortality, 6.1 per 1,000 PY for extrahepatic cancerspecific mortality, and 2.2 per 1,000 PY for liver-specific mortality [50]
According to the researchers, Contrary to reports of increases in suicidal ideation with semaglutide, our analyses revealed a lower risk for both incidence and recurrence of suicidal ideation in patients prescribed semaglutide compared with non-GLP1R agonist anti-obesity and anti-diabetes medications. 20 If you look at the study a little bit deeper there was a decreased risk in [suicidal ideation] in women, men and along every racial group, said Catherine Varney, DO, obesity medicine director for UVA Health and an assistant professor of family medicine at the University of Virginia
J Cardiovasc Magn Reson 20(1):80
But those retractions also play a necessary role
Tirzepatide adds GIP receptor activation to the GLP-1 pathway, offering dual hormone signaling that may provide weight loss benefits while maintaining a similar gastrointestinal safety profile
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