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High glucose can elicit extracellular Ca 2+ influx via voltage-dependent Ca 2+ channel (VDCC) [66,67,68]

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As depicted in Figure 2A, cholesterol stimulation significantly decreased, while EX-4 treatment increased the phosphorylation of AMPK and could reverse the effect of cholesterol stimulation in INS-1 cells, suggesting the involvement of AMPK signaling

Efficacy and Safety of GLP-3, a Novel GLP-1, GIP, and Glucagon Receptor Agonist for Obesity Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Abdrabou Abouelmagd A