Muscle loss with GLP-1RAs is probably proportional to the extent of weight loss, and resistance exercise with adequate protein intake is recommended to preserve muscle mass and function
Unlike semaglutide (Ozempic/Wegovy), which targets a single receptor (GLP-1), or tirzepatide (Mounjaro/Zepbound), a dual agonist for GLP-1 and GIP receptors, retatrutide goes one step further and acts as a triple agonist targeting GLP-1, GIP and glucagon receptors
There is no preservative, and so it cannot be stored
Once opened, a vial remains sterile for up to 28 days when proper aseptic technique is maintained
Xiong X, Barreto GE, Xu L, Ouyang YB, Xie X, Giffard RG
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