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The single-cycle adenovirus replicates its genome (including the encoded spike transgene) 10,000 times but does not produce infectious virions

(PubMed) Seshadri S, Beiser A, Selhub J, et al

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Compared with similar published cases, our patient had an exceptionally low pH (6.9) and bicarbonate level (1.7 mmol/L) and is among the most severe [1, 5, 6] Table 1 presents a summary of some of the cases published to date