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As a result, lifestyle interventions alone, such as diet and exercise, are often insufficient, and effective management typically requires a combination of strategies to address the underlying biology of obesity. The group explored data from more than 60,000 patients who originally participated in one of 56 randomized controlled trials (RCTs)

This work is supported by grants from Guangxi Elite Team of Medicinal Plant Conservation, and 2022 Nanshan District Science and Technology Plan Project (No: NS2022008, Key Program)

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Together, these methyl-donating nutrients support energy metabolism, nerve signaling, and cardiovascular health

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10.1056/NEJMOA1603827 29 MasiS.RizzoniD.TaddeiS.WidmerR