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So when performing an IPGTT after 30 min of the dosing, the native peptide 1 was already inactive while hybrid 14 demonstrated full activity as predicted again from the blood glucose study

Consistent with this, GIPR is expressed in the hypothalamus (156) and the hindbrain (157, 188) and DREADD-mediated activation of GIPR neurons/cells in the hypothalamus decreases food intake in rodents (156)