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Chronic hyperglycemia can induce mitochondrial permeability transition, which compromises mitochondrial function and exacerbates cellular injury in diabetic hearts (Sloan et al., 2012)

The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features

2.11 Co-culture and wound healing assay MCECs were seeded into 6-well plates and cultured for 24 h

J Pineal Res 59(4):403419 Mannino G, Pernici C, Serio G, Gentile C, Bertea CM (2021) Melatonin and phytomelatonin: chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animalsan overview

the trials were small (ranging from 20 to 193 subjects) and their design was so different that results could not be generalized

Some studies suggest that it may also help with autoimmune conditions, where the immune system attacks healthy tissues