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Some researchers use weekly dosing most of the time and switch to split dosing during periods when side effects are particularly bothersome, such as during dose escalation

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Discussion As one of the most complex biological processes that occur during human life, the wound repair process involves four steps that include inflammation around the site of injury, angiogenesis and the development of granulation tissue, repair of the connective tissue and epithelium, and ultimately remodeling that leads to a healed wound

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ISF, Interstitial fluid