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For men with obesity-associated functional hypogonadism, these medications offer a fertility-preserving therapeutic option

In addition, fasting ApoB-48 is associated with the incidence of coronary artery disease, and elevated ApoB-48 levels, together with risk factors for metabolic syndrome, exacerbate the risk of coronary artery disease 35

169 SIRT1 activates antioxidant transcription factors such as FOXO3a and Nrf2 via deacetylation, 170 upregulating enzymes including superoxide dismutase (SOD) 1/2, GSH-Px, 171 and HO-1

Semaglutide trials (SUSTAIN series) reported nausea in roughly 37% of participants at higher doses, while tirzepatide trials (SURMOUNT series) documented nausea in 2633% across dose tiers

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