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With advancing age, GH secretion declines in postmenopausal women, whereas a decline in serum T is directly associated with decreases in indices of GH secretion in older men (22)

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HO-1 plays a significant function in vascular tissues by safeguarding endothelial cells from various apoptotic stimuli, thereby regulating endothelial cell cycle control, proliferation, vascular endothelial growth factor (VEGF) secretion, and angiogenesis [94, 95]