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on the other hand, new targets like ACSL5 and ActRII are emerging, establishing differentiated values such as "fat loss without muscle loss" and "maintaining long-term efficacy." Furthermore, the convenience of drug administration has also become a competitive dimension of interest for many pharmaceutical companies

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The brain: quieting "food noise." GLP-1 receptors in the hypothalamus and reward centers reduce appetite and the intrusive thoughts about food that many patients with obesity describe

Obesity 14 , 529644 (2006)

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When you eat carbohydrates, glucose travels through your gastrointestinal tract, where specialized cells in the small intestine release hormones called GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide)