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Tapering the medication under medical supervision, adopting lifestyle changes, and utilizing supportive therapies can significantly ease the transition

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By inhibiting P-gp, these agents enhance cellular drug retention but may inadvertently increase systemic drug concentrations, posing toxicity risks for narrow-therapeutic-index medications (e.g., chemotherapeutics, cardiovascular drugs) (32, 8890)

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Spermidine may regulate the Akt/FHC/ACSL4 pathway to inhibit ferroptosis in porcine ovarian granulosa cells, with possible implications for ovarian reserve and fertility (Niu et al., 2023)