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Tear fluid was collected from 60 participants, cognitively normal (CN) individuals ( n = 32), patients with mild cognitive impairment ( n = 14), and dementia ( n = 14)

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Lipid peroxidation and ferroptosis promote bone loss in subchondral bone The modification of subchondral bone, including early-stage bone loss, late-stage bone sclerosis and histopathological alterations, plays an important role in the pathogenesis of OA [129]