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Dietary nickel chloride restrains the development of small intestine in broilers

It has been demonstrated that the recruitment of ARL8 to the surface of lysosomes and lysosome-related organelles is promoted by the evolutionarily conserved multisubunit BLOC-one-related complex (BORC) 26,27 , but the underlying mechanism remains uncertain

In response to OS, different metabolites oxidize highly reactive cysteine residues in KEAP1, inducing a conformational change in the KEAP1-NEDD8-CUL3-RBX1-E3 ubiquitin ligase complex, with an improper orientation of Lys residues on NRF2 [122, 158]

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