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Anal Biochem 89(2):430436 Acknowledgements We thank all of our colleagues for their continuous encouragement and helpful scientific comments

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Glycine 1228 is the sole residue responsible for the stimulation of GSH transport and associated collateral sensitivity in TM16-TM17 To characterize the effect of the original replacement within the nine identified clusters of chimera M8, we first verified that all the mutants were well expressed and addressed to the plasma membrane (Supplementary Fig