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To be a candidate for a weight loss peptide, namely a GLP-1 RA, you typically need to meet one or several of the following diagnostic criteria: Obesity: Obesity is defined as having a body mass index (BMI) above 30 (e.g., someone whos 511 and weighs 215lb would qualify as obese),22 but a BMI slightly below 30 doesnt disqualify you for a peptide prescription

But, as Marks points out, 'Unfortunately amino-acid sequencing was not then as reliable as it later became and in the case of GIP was wrong

September 29, 2025

Interestingly, Gabery et al

GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy, Rybelsus) have significantly improved the management of obesity and type 2 diabetes, providing effective weight loss and cardiometabolic benefits

GIP receptor agonism attenuates GLP-1 receptor agonist-induced nausea and emesis in preclinical models