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The GLP-1 drug participants had no progression of motor symptoms (-0.04), and the 3.04 worsening in the placebo group (difference between the two arms=3.08) is just short of what is considered clinically meaningful (3.5)

As mentioned by the authors, the findings of this review should be viewed with some caution with respect to the potential therapeutic effect of GLP-1 receptor agonists on substance use disorder