The Grimace scale was used to assess spontaneous pain, while mechanical and thermal sensitivities were evaluated using Von Frey, Randall-Sellito, hind paw cold allodynia, and hot plate tests
Huang et al., 2024)
Other patients also experienced clinical improvements, including a 6 year old boy with severe diabetes, ketosis (accumulation of ketones, a term first used by the German chemist Leopold Gmelin - figure 5), heavy glycosuria and malnutrition (de Levia, Brugus, de Leiva-Prez)
Within this landscape, tirzepatide stands out because of its dual GIP/GLP-1 mechanism, which produces superior weight loss compared to GLP-1-only medications
If compounding becomes further restricted, your prescriber can help you transition to commercial Mounjaro, switch to compounded semaglutide which has different regulatory status, or explore other weight management options
Monitoring: Weigh yourself weekly, measure body composition monthly if possible