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[DOI] [PubMed] [Google Scholar] 38.Ng KL, Davidson JS, Bathgate AJ

These findings indicate potential pathways through which incretin therapy may: Stimulate bone formation by activating osteoblasts Inhibit bone resorption via osteoclast suppression Influence calcium and phosphate homeostasis Together, these mechanisms offer biologic plausibility that GLP1 RAs could help preserve bone strength

Dose reduction should be considered if hypoglycemia occurs

IM injections are a more effective way to deliver these medications

It is not a hormone replacement

MT-1s potent MC1R activation drives melanin synthesis independent of UV radiation , providing experimental control over the melanogenesis pathway without the confounding DNA damage, oxidative stress, and inflammatory responses that UV exposure produces alongside its melanogenic effects