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The relationship between the AGE-RAGE system and infertility was also documented: AGEs have a negative effects on the reproductive outcome in women undergoing ART (assisted reproduction technology), AGE high levels in NON PCOS women appear to be related to the decrease in ovarian reserve and abnormal folliculogenesis
Biochem Biophys Res Commun 359:269276 Vikman J, Jimenez-Feltstrom J, Nyman P, Thelin J, Eliasson L (2009) Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol
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