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Conclusions The currently available evidence on the mechanisms of action and clinical effects of GLP-1/GIP dual agonism supports very optimistic prospects for the future use of tirzepatide

[DOI] [PubMed] [Google Scholar] 40.Deters M., Strubelt O., Younes M

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After binding and activation of its receptor, insulin, as an anabolic hormone, promotes increased biosynthesis of macromolecules further needed to maintain energetic balance during nutrient privation ( At cellular level, insulin mostly relies on the specific bind to its transmembrane receptor to perform its actions (Figure 1)

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BPA binding to AR increases cyp19a1b expression in brains of zebrafish larvae 34 and ar transcripts are present in developing retina 96 , suggesting a potential mechanism in this tissue