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DJD and KDM wrote the manuscript

Receptor-mediated transcytosis of macromolecules across the blood-brain barrier

NHS weight management pathways follow NICE guidance, which recommends licensed treatments such as orlistat, semaglutide (Wegovy), or tirzepatide (Mounjaro) alongside lifestyle interventions

MR is strongly recommended as a means of prioritizing drug targets for cardiovascular research, to avoid expensive failures in phase III randomized controlled trials (RCTs) [18, 19] and to identify mechanistic targets of intervention, complementary to RCTs [19]

Significant differences in RQ were observed at several time points (e.g., 3 min ( p = 0.039), 5 min ( p = 0.017, r = 0.67), 7 min ( p = 0.027)) when L-carnitine was consumed, highlighting that the supplementation led to increased fat oxidation and decreased carbohydrate reliance, especially during the early and middle phases of exercise

As the prescribed dose reaches its optimal level, significant weight loss can occur, often helping patients lose several pounds per week