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Clinical studies most often report mild side effects, including nausea, vomiting, diarrhea, heartburn, gas, headache, and general digestive discomfort.27 A 2021 safety review of high-dose NAC in chronic respiratory diseases found that oral doses between 600mg and 3,000mg daily were generally well tolerated, with gastrointestinal symptoms reported but not consistently more often than placebo.35 That doesnt mean NAC is risk-free
However, both drugs are associated with side effects such as scalp dryness, skin irritation, erectile dysfunction, and testicular pain (Ruksiriwanich et al., 2022)
Timeline expectations: 48-72 hours (increased energy and reduced appetite), 1-2 weeks (initial weight loss 2-4 pounds), 4 weeks (noticeable body composition improvements), and 6 weeks (sustained metabolic enhancement and continued fat loss)
This is especially true in the liver, which has high levels of glutathione
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