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Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice

As such, therapeutic strategies targeted on these events may not be beneficial at last, a concern that has been reflected in certain preclinical studies

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Neurobiology of Learning and Memory, 149, 6876