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Rushworth and I

Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-induced impairment of spatial memory

It potentially reduces inflammation by increasing microRNA-146a expression, thereby decreasing pro-inflammatory cytokines IRAK1 and TRAF6 [27]

In particular, this variant produces an altered fixation of SP1 and PC4 transcription factors in the promoter, resulting in a decreased transcription activity (Sousa et al., 2009) and rs38841 in Japanese population patients (Thanseem et al., 2010)

(PubMed) Wolthers KR, Scrutton NS

Other factors which involve a lack of information and potentially contribute to heterogeneity include concomitant illnesses and medications, both of which may affect antioxidant status