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The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species

The GSH overexpression then foster the survival and proliferation of tumor cells

The clinical impact of this reduced susceptibility is unknown

Two of the three structurally related compounds (afamelanotide and bremelanotide) reached FDA approval in 2019 for narrow orphan or single-indication uses