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Clinical evidence shows that stopping GLP-1 therapy usually leads to weight regain and worsening blood sugar control

Gradual dose reduction may help stabilize appetite signals during the transition

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4.4 Systemic risk biomarkers Retinal vascular changes, such as arteriolar narrowing, venular dilation, and tortuosity, serve as biomarkers for systemic complications, including hypertension, stroke, and CKD (135)

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A good candidate should be comfortable with self-administering injections or have a support system to assist with injections