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Similar to the SGLT2 inhibitors [1, 4, 13], GLP-1RAs also mildly reduced systolic and diastolic blood pressure in the trials

Interestingly, a post-hoc analysis of the Prediabetes Lifestyle Intervention Study (PLIS) suggested that patients achieving prediabetes remission differed from non-responders in improvement in whole body insulin sensitivity, visceral adipose tissue (VAT) and intrahepatic fat rather than insulin secretion upon a similar weight loss 76

An open-label extension to a previous phase 2a study is ongoing in adults with SCD (ClinicalTrials.gov Identifier: NCT04053803) (McArthur et al., 2019)

Frequency: 12 injections per day

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Though broccoli sprouts may be able to eradicate H