The underlying mechanisms of cardiovascular and renal protection differ partially between GLP1-RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (primarily systemic and intrarenal hemodynamic changes)
IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial
Rapid weight loss, hormonal changes, and improved insulin sensitivity may lead to missed periods, irregular cycles, spotting, or changes in menstrual flow
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