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Nature 2003, 426 (6968), 884890

500mg of standard glutathione may result in less cellular benefit than 100mg of liposomal glutathione, because the liposomal version actually reaches the bloodstream intact

The key is how these signals are structured and integrated within the tissue

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doi: 10.1038/s41598-023-45787-9

DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon