Aside from the many side effects associated with barbiturate use, StatPearls states that allergic reactions can also occur especially with phenobarbital use
Depending on the etiology, the stone may be composed of a mixture of cholesterol, calcium salts, hemoglobin, and occasionally as a pure stone composed of just one of these substances
Headaches and dizziness Headaches are reported by a significant minority of patients, particularly early in treatment
Cheng, Y.C., et al
Repeated cortico-striatal stimulation generates persistent OCD-like behavior
Additionally, synthesis of prodrugs like -glutamyl 3,4-dihydroxyphenylalanine (L-DOPA) has been reported to have increased half-life due to resistance to cleavage by general serum proteases (Misicka et al., 1996)